The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity

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• 作者：Huan Wang ; Dusan Hesek ; Mijoon Lee ; Elena Lastochkin ; Allen G. Oliver ; Mayland Chang ; Shahriar Mobashery
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：1219-1222
• 全文大小：233K
• 年卷期：0
• ISSN：1520-6025

文摘

Four possible isomers of essramycin, a natural product from a marine Streptomyces species isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by ¹H NMR, ¹³C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.