Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses

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• 作者：Ryan J. Conrad ; Melanie Ott
• 刊名：ACS Chemical Biology
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：11
• 期：3
• 页码：669-680
• 全文大小：679K
• ISSN：1554-8937

文摘

Persistent viral infections are widespread and represent significant public health burdens. Some viruses endure in a latent state by co-opting the host epigenetic machinery to manipulate viral gene expression. Small molecules targeting epigenetic pathways are now in the clinic for certain cancers and are considered as potential treatment strategies to reverse latency in HIV-infected individuals. In this review, we discuss how drugs interfering with one epigenetic pathway, protein acetylation, perturb latency of three families of pathogenic human viruses—retroviruses, herpesviruses, and papillomaviruses.