Asymmetric Deprotonation−Substitution of N-Pop-benzylamines Using [RLi/(−)-Sparteine]. Enantioselective Sequential Reactions and Synthesis of N-Heterocycles

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• 作者：Pascual Oñ ; a-Burgos ; Ignacio Ferná ; ndez ; Laura Roces ; Laura Torre-Ferná ; ndez ; Santiago Garcí ; a-Granda ; Fernando Ló ; pez-Ortiz
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：August 7, 2008
• 年：2008
• 卷：10
• 期：15
• 页码：3195-3198
• 全文大小：203K
• 年卷期：v.10,no.15(August 7, 2008)
• ISSN：1523-7052

文摘

Pop-directed asymmetric deprotonation of benzylic amines using [n-BuLi/(−)-sparteine] provides an efficient method for the synthesis of chiral NC_α and NC_α,α′ derivatives with total selectivity with respect to competing allylic and ortho lithiation. The method described herein offers a straightforward route of accessing chiral N-Pop-protected nitrogen heterocycles.