Identification of Inhibitors for UDP-Galactopyranose Mutase

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• 作者：Michelle Soltero-Higgin ; Erin E. Carlson ; John H. Phillips ; and Laura L. Kiessling
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：September 1, 2004
• 年：2004
• 卷：126
• 期：34
• 页码：10532 - 10533
• 全文大小：41K
• 年卷期：v.126,no.34(September 1, 2004)
• ISSN：1520-5126

文摘

The flavoenzyme uridine 5'-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16 000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified.