文摘
The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure鈥揳ctivity relationship (SAR) of the first potent, selective series of inhibitors of the BRPF1 bromodomain.
Keywords:
BRPF1; BRPF2; BRD1; BRPF3; bromodomain; chemical probe; epigenetics; fragment; inhibitor