Efficient Solid-Phase Synthesis of a Library of Imidazo[1,2-a]pyridine-8-carboxamides
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- 作者：Ahmed Kamal ; V. Devaiah ; K. Laxma Reddy ; Rajendar ; Rajesh V. C. R. N. C. Shetti ; N. Shankaraiah
- 刊名：Journal of Combinatorial Chemistry
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：9
- 期：2
- 页码：267 - 274
- 全文大小：142K
- 年卷期：v.9,no.2(March 2007)
- ISSN：1520-4774
文摘
A versatile method for the solid-phase synthesis of imidazo[1,2-a]pyridine-based derivatives, imidazo[1,2-a]pyridine-8-carboxamides, has been developed. They were obtained by treatment of the amino group ofthe polymer-bound 2-aminonicotinate with different 
-haloketones, followed by halogenation at the 3-positionof the polymer-bound imidazo[1,2-a]pyridine. The derived polymer-bound imidazo[1,2-a]pyridines 5, 6,and 7 were finally cleaved from the solid-support with an excess of primary or secondary amines. The finalcrude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE).
-haloketones, followed by halogenation at the 3-positionof the polymer-bound imidazo[1,2-a]pyridine. The derived polymer-bound imidazo[1,2-a]pyridines 5, 6,and 7 were finally cleaved from the solid-support with an excess of primary or secondary amines. The finalcrude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE).