From Styrenes to Enantiopure -Arylglycines in Two Steps
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- 作者：K. Laxma Reddy and K. Barry Sharpless
- 刊名：Journal of the American Chemical Society
- 出版年：1998
- 出版时间：February 18, 1998
- 年：1998
- 卷：120
- 期：6
- 页码：1207 - 1217
- 全文大小：182K
- 年卷期：v.120,no.6(February 18, 1998)
- ISSN：1520-5126
文摘
Direct enantioselective synthesis of (R)-and (S)-N-Cbz- or N-BOC-protected
-arylglycinols fromstyrenes via catalytic asymmetric aminohydroxylation, withenantioselectivities up to 99% and isolated yieldsup to 80%, is described. In a subsequent oxidation step, theseglycinols yield the corresponding carbamate-protected -arylglycines.
-arylglycinols fromstyrenes via catalytic asymmetric aminohydroxylation, withenantioselectivities up to 99% and isolated yieldsup to 80%, is described. In a subsequent oxidation step, theseglycinols yield the corresponding carbamate-protected -arylglycines.