Biomimetic Synthesis of (-)-Longithorone A

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• 作者：Mark E. Layton ; Carl A. Morales ; and Matthew D. Shair
• 刊名：Journal of the American Chemical Society
• 出版年：2002
• 出版时间：February 6, 2002
• 年：2002
• 卷：124
• 期：5
• 页码：773 - 775
• 全文大小：56K
• 年卷期：v.124,no.5(February 6, 2002)
• ISSN：1520-5126

文摘

An enantioseletive, biomimetic synthesis of (-)-longithorone A has been achieved using an intermolecular/transannular Diels-Alder sequence which provides some support for the proposed biosynthesis. The cycloaddition precursors were two [12]-paracyclophanes that were constructed with atropisomer control during ene-yne metathesis macrocyclizations.