文摘
NaNO<sub>3sub> is used in oxidative Pd-catalyzed processes as a complementary co-catalyst to common oxidants, e.g., Cu<sup>IIsup> salts, in C–H bond activation and Wacker oxidation processes. NaNO<sub>3sub> and NaNO<sub>2sub> (with air or O<sub>2sub>) assist the sp<sup>3sup>-C–H bond acetoxylation of substrates bearing an N-directing group. It has been proposed previously that a redox couple is operative. The role played by NO<sub>xsub> anions is examined in this investigation. Evidence for an NO<sub>xsub> anion interaction at Pd<sup>IIsup> is presented. Palladacyclic complexes containing NO<sub>xsub> anions are competent catalysts for acetoxylation of 8-methylquinoline, with and without exogenous NaNO<sub>3sub>. The oxidation of 8-methylquinoline to the corresponding carboxylic acid has also been noted at Pd<sup>IIsup>. <sup>18sup>O-Labeling studies indicate that oxygen derived from nitrate appears in the acetoxylation product, the transfer of which can only occur by interaction of <sup>18sup>O at Pd with a coordinating-acetate ligand. Nitrated organic intermediates are formed under catalytic conditions, which are converted to acetoxylation products, a process that occurs with (50 °C) and without Pd (110 °C). A catalytically competent palladacyclic dimer intermediate has been identified. Head-space analysis measurements show that NO and NO<sub>2sub> gases are formed within minutes on heating catalytic mixtures to 110 °C from room temperature. Measurements by in situ infrared spectroscopy show that N<sub>2sub>O is formed in sp<sup>3sup>-C–H acetoxylation reactions at 80 °C. Studies confirm that cyclopalladated NO<sub>2sub> complexes are rapidly oxidized to the corresponding NO<sub>3sub> adducts on exposure to NO<sub>2sub>(g). The investigation shows that NO<sub>xsub> anions act as participating ligands at Pd<sup>IIsup> in aerobic sp<sup>3sup>-C–H bond acetoxylation processes and are involved in redox processes.