Synthesis of Ethyl Nalidixate: A Medicinal Chemistry Experiment
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- 作者：Ray Leslie ; Elaine Leeb ; Robert B. Smith
- 刊名：Journal of Chemical Education
- 出版年：2012
- 出版时间：January 1, 2012
- 年：2012
- 卷：89
- 期：1
- 页码：144-146
- 全文大小：679K
- 年卷期：v.89,no.1(January 1, 2012)
- ISSN：1938-1328
文摘
A series of laboratory experiments that complement a medicinal chemistry lecture course in drug design and development have been developed. The synthesis of ethyl nalidixate covers three separate experimental procedures, all of which can be completed in three, standard three-hour lab classes and incorporate aspects of green chemistry such as solvent-free reaction conditions and minimizing purification procedures. The experimental procedures are straightforward and require no specialized equipment, although access to IR and NMR spectrometers for spectral analysis is beneficial. Both the experimental and theoretical aspects of the synthesis are sufficiently challenging for a year-two undergraduate chemistry class.