Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes
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- 作者：S. Sarath Chand ; Greeshma Gopalan ; P. V. Santhini ; P. Preethanuj ; Jubi John ; Dominique Harakat ; Florian Jaroschik ; K. V. Radhakrishnan
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：March 4, 2016
- 年：2016
- 卷：18
- 期：5
- 页码：964-967
- 全文大小：405K
- ISSN：1523-7052
文摘
A diverse approach toward the catalytic regioselective nucleophilic addition of nitrogen heterocycles to Lewis acid activated pentafulvenes has been established. The developed protocol introduces pentafulvenes as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing alkylidenecyclopentenylation at the C-3 position of indoles and the C-2 position of pyrrole.