Divergent Synthesis of Benzene Derivatives: Br酶nsted Acid Catalyzed and Iodine-Promoted Tandem Cyclization of 5,2-Enyn-1-ones

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• 作者：Fang Yang ; Yi-Feng Qiu ; Ke-Gong Ji ; Yan-Ning Niu ; Shaukat Ali ; Yong-Min Liang
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：October 19, 2012
• 年：2012
• 卷：77
• 期：20
• 页码：9029-9037
• 全文大小：371K
• 年卷期：v.77,no.20(October 19, 2012)
• ISSN：1520-6904

文摘

Highly substituted benzene derivatives, including alkoxy-, iodoalkoxy-, and diiodo-substituted benzenes, can be selectively synthesized via Br酶nsted acid catalyzed and iodine-promoted tandem carbocyclization respectively. This reaction involved a direct process for C鈥揅 bond formation from 5,2-enyn-1-ones, and different reaction systems (Br酶nsted acids/electrophiles with solvents) afforded different substituted benzenes. Furthermore, the halogenated moiety and alkoxy group can be readily introduced into the benzene in a position which has not been easily obtained previously.