文摘
Highly substituted benzene derivatives, including alkoxy-, iodoalkoxy-, and diiodo-substituted benzenes, can be selectively synthesized via Br酶nsted acid catalyzed and iodine-promoted tandem carbocyclization respectively. This reaction involved a direct process for C鈥揅 bond formation from 5,2-enyn-1-ones, and different reaction systems (Br酶nsted acids/electrophiles with solvents) afforded different substituted benzenes. Furthermore, the halogenated moiety and alkoxy group can be readily introduced into the benzene in a position which has not been easily obtained previously.