Tandem Rh(III)-Catalyzed C–H Amination/Annulation Reactions: Synthesis of Indoloquinoline Derivatives in Water

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• 作者：Liangliang Shi ; Baiquan Wang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2820-2823
• 全文大小：388K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient Rh(III)-catalyzed synthetic method for indoloquinoline derivatives from readily available indoles and isoxazoles was developed. This annulation procedure undergoes tandem C–H activation, cyclization, and condensation steps. In this domino cyclization reaction, water is an efficient solvent. A catalytically competent five-membered rhodacycle has been isolated and characterized, thus revealing a key intermediate in the catalytic cycle.