Asymmetric Synthesis of Spiro-3,4-dihydropyrans via a Domino Organocatalytic Sequence

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• 作者：Weijun Yao ; Lianjie Pan ; Yihua Wu ; Cheng Ma
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2422-2425
• 全文大小：180K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

A cinchona alkaloid-catalyzed domino Michael/hemiacetalization reaction of cyclic β-oxo aldehydes and aromatic β,γ-unsaturated α-keto esters, resulting in the formation of spiro-dihydropyran architectures in good yield with high stereoselectivity (up to 97% ee), is presented.