Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)2-Catalyzed Annulation of N-Allylamidines

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• 作者：Li Xu ; Hongxian Li ; Ziyang Liao ; Kaiyan Lou ; Hexin Xie ; Hao Li ; Wei Wang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：17
• 期：14
• 页码：3434-3437
• 全文大小：278K
• ISSN：1523-7052

文摘

A Pd(OAc)₂-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O₂ from air and/or a ligand and Pd(OAc)₂, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.