Solid-Phase Total Synthesis of Cyclic Decapeptide Phakellistatin 12
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- 作者：Liaqat Ali ; Syed Ghulam Musharraf ; Farzana Shaheen
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：71
- 期：6
- 页码：1059 - 1062
- 全文大小：96K
- 年卷期：v.71,no.6(June 2008)
- ISSN：1520-6025
文摘
Pakellistatin 12 (1) is a new cancer cell growth inhibitory (P388 ED50 2.8 µg/mL) cyclodecapeptide that was isolated from a marine sponge Phakellia sp. The first total synthesis of compound 1 is reported here using solid-phase methodology with safety-catch linker strategy. For the sequence of amino acids in the cycle, the peptide product was analyzed with a MALDI TOF/TOF instrument, and the structure of the synthetic product was found to be chemically and spectroscopically identical to the natural substance.