An Amphiphilic Perylene Imido Diester for Selective Cellular Imaging

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• 作者：Timm Heek ; J枚rg Nikolaus ; Roland Schwarzer ; Carlo Fasting ; Pia Welker ; Kai Licha ; Andreas Herrmann ; Rainer Haag
• 刊名：Bioconjugate Chemistry
• 出版年：2013
• 出版时间：February 20, 2013
• 年：2013
• 卷：24
• 期：2
• 页码：153-158
• 全文大小：383K
• 年卷期：v.24,no.2(February 20, 2013)
• ISSN：1520-4812

文摘

A new amphiphilic membrane marker based on a water-soluble dendritic polyglycerol perylene imido dialkylester has been designed, synthesized, and its optical properties characterized. In water it forms fluorescently quenched micellar self-aggregates, but when incorporated into a lipophilic environment, it monomerizes, and the highly fluorescent properties of the perylene core are recovered. These properties make it an ideal candidate for the imaging of artificial and cellular membranes as demonstrated by biophysical studies.