Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with a Matrix of Carbon Nanotubes for the Analysis of Low-Mass Compounds in Environmental Samples

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• 作者：Ligang Hu ; Songyun Xu ; Chensong Pan ; Chungang Yuan ; Hanfa Zou ; and Guibin Jiang
• 刊名：Environmental Science & Technology
• 出版年：2005
• 出版时间：November 1, 2005
• 年：2005
• 卷：39
• 期：21
• 页码：8442 - 8447
• 全文大小：120K
• 年卷期：v.39,no.21(November 1, 2005)
• ISSN：1520-5851

文摘

The use of matrix-assisted laser desorption/ionizationtime-of-flight mass spectrometry (MALDI-TOF-MS) forenvironmental analysis has been mainly focused on qualitativeanalysis of high-mass molecules, such as toxins, humicacid, and microorganisms. Herein, we describe a novel MALDI-TOF-MS method with a matrix of oxidized carbon nanotubesfor analysis of low-mass compounds in environmentalsamples. A number of chemicals in the environment werequalitatively analyzed by the present method, and it wasfound that most of them, especially the highly polar chemicals,were measurable with high sensitivity. With the intrinsicability to measure high-mass chemicals, this method cancompensate for the current shortage of methods forenvironmental analysis for the measurement of highlypolar or high-mass chemicals. For sample analysis, arsenicspeciation in Chinese traditional medicines was qualifiedand diphenylolpropane in water samples was quantified. Withthe relatively high tolerance of the method to interferingmolecules, a simple pretreatment or even no pretreatmentcould be employed before MS detection. Furthermore,this method can be employed in a high-throughput format.