Graphene Oxide鈥揝ilver Nanocomposite As a Highly Effective Antibacterial Agent with Species-Specific Mechanisms
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- 作者：Jia Tang ; Qian Chen ; Ligeng Xu ; Shuai Zhang ; Liangzhu Feng ; Liang Cheng ; Huan Xu ; Zhuang Liu ; Rui Peng
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2013
- 出版时间：May 8, 2013
- 年：2013
- 卷：5
- 期：9
- 页码：3867-3874
- 全文大小：467K
- 年卷期：v.5,no.9(May 8, 2013)
- ISSN：1944-8252
文摘
Recently, graphene oxide (GO) based nanocomposites have raised significant interests in many different areas, one of which being antibacterial agents where sliver nanoparticle (AgNPs) anchored GO (GO鈥揂g) has shown promising potential. However, to our best knowledge, factors affecting its antibacterial activity as well as the underlying mechanism remain unclear. In this study, we fabricate GO鈥揂g nanocomposites with different AgNPs to GO ratios and carefully investigate their antibacterial activities against both the Gram-negative (G鈭? bacteria Escherichia coli (E. coli) and the Gram-positive (G+) bacteria Staphylococcus aureus (S. aureus). We discover that, compared to AgNPs, GO鈥揂g nanocomposite with an optimal ratio of AgNPs to GO is much more effective and shows synergistically enhanced, strong antibacterial activities at rather low dose (2.5 渭g/mL). The GO鈥揂g nanocomposite is more toxic to E. coli than that to S. aureus. The antibacterial effects of GO鈥揂g nanocomposite are further investigated, revealing distinct, species-specific mechanisms. The results demonstrate that GO鈥揂g nanocomposite functions as a bactericide against the G鈥?E. coli through disrupting bacterial cell wall integrity, whereas it exhibits bacteriostatic effect on the G+ S. aureus by dramatically inhibiting cell division. Our work not only highlights the great promise of using GO鈥揂g as a highly effective antibacterial agent but also provides more in-depth understandings of the interactions between microorganisms and GO-based nanocomposites.