Vitamin B2 Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death via Modulation of Akt and Bad Phosphorylation

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• 作者：Ni Chen ; Shutao Yin ; Xinhua Song ; Lihong Fan ; Hongbo Hu
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：August 5, 2015
• 年：2015
• 卷：63
• 期：30
• 页码：6739-6748
• 全文大小：527K
• ISSN：1520-5118

文摘

Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B₂, another essential dietary nutrient, often coexists with vitamin C in some fruits, vegetables, or dietary supplements. The objective of the present study is to determine whether the combination of vitamin C and B₂ can achieve a synergistic anticancer activity. MDA-MB-231, MCF-7, and A549 cells were employed to evaluate the combinatory effects of vitamin C and B₂. We found that the combination of vitamin C and B₂ resulted in a synergistic cell death induction in all cell lines tested. Further mechanistic investigations revealed that vitamin B₂ sensitized cancer cells to vitamin C through inhibition of Akt and Bad phosphorylation. Our findings identified vitamin B₂ as a promising sensitizer for improving the efficacy of vitamin-C-based cancer chemoprevention and chemotherapy.