Phosphorescent Coordination Polymer Nanoparticles as a Three-in-One Platform for Optical Imaging, T1-Weighted Magnetic Resonance Imaging, and Photodynamic Therapy

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• 作者：Yang Lu ; Fengfeng Xue ; Hong Yang ; Min Shi ; Yuping Yan ; Lijie Qin ; Zhiguo Zhou ; Shiping Yang
• 刊名：Journal of Physical Chemistry C
• 出版年：2015
• 出版时间：January 8, 2015
• 年：2015
• 卷：119
• 期：1
• 页码：573-579
• 全文大小：458K
• ISSN：1932-7455

文摘

Water-soluble coordination polymer nanoparticles (Ir鈥揋d CPPs) were conveniently synthesized in high yields in the presence of polyvinylpyrrolidone (PVP), adopting magnetic Gd(III) ions, and phosphorescent iridium complexes with carboxyl groups as building blocks. The Ir鈥揋d CPPs showed good stability in simulated biological media and low cytotoxicity toward a model line of HeLa cancer cells. The Ir鈥揋d CPPs exhibited absorption in the visible region, red phosphorescence centered at 560 nm, and higher longitudinal relaxivity (r₁) of 鈭?9.5 mM^鈥? s^鈥? in a 3 T MRI system. Furthermore, the effective uptake of Ir鈥揋d CPPs by HeLa cells was confirmed by confocal laser scanning microscopy and flow cytometry, suggesting they may be useful as an optical probe for living cells. The generation of ¹O₂ upon irradiation with a visible light prompted an investigation into the possibility of using Ir鈥揋d CPPs in photodynamic therapy. After incubation with 200 渭g mL^鈥? of Ir鈥揋d CPPs for 6 h, the viability of HeLa cells was only 鈭?6.6% after irradiation with a visible light (位 > 400 nm, 300 mW cm^鈥?).