An Efficient Approach to 3-Bromo-6-chloro-phenanthrene-9,10-dione

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• 作者：John Limanto ; Benjamin T. Dorner ; Frederick W. Hartner ; Lushi Tan
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：November 21, 2008
• 年：2008
• 卷：12
• 期：6
• 页码：1269-1272
• 全文大小：135K
• 年卷期：v.12,no.6(November 21, 2008)
• ISSN：1520-586X

文摘

A practical and efficient synthesis of 3-bromo-6-chloro-phenanthrene-9,10-dione was developed and demonstrated on a large scale. The synthetic approach involves six chemical steps and two isolations in 73% overall yield. The key transformations feature an anionic cyclization for generation of the phenanthrene ring, followed by sequential tribromination and hydrolysis for the incorporation of the bromo-diketone functionality.