Practical and Cost-Effective Manufacturing Route for the Synthesis of a β-Lactamase Inhibitor
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- 作者：Steven P. Miller ; Yong-Li Zhong ; Zhijian Liu ; Michael Simeone ; Nobuyoshi Yasuda ; John Limanto ; Zheng Chen ; Joseph Lynch ; Vincent Capodanno
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：January 3, 2014
- 年：2014
- 卷：16
- 期：1
- 页码：174-177
- 全文大小：315K
- ISSN：1523-7052
文摘
Compound 1, a potent and irreversible inhibitor of 尾-lactamases, is in clinical trials with 尾-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.