New Bicyclo[3.1.0]hexane Unit ent-Kaurane Diterpene and Its seco-Derivative from Isodon eriocalyx var. laxiflora
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- 作者：Wei-Guang Wang ; Xue Du ; Xiao-Nian Li ; Hai-Yan Wu ; Xu Liu ; Shan-Zhai Shang ; Rui Zhan ; Cheng-Qin Liang ; Ling-Mei Kong ; Yan Li ; Jian-Xin Pu ; Han-Dong Sun
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：January 6, 2012
- 年：2012
- 卷：14
- 期：1
- 页码：302-305
- 全文大小：251K
- 年卷期：v.14,no.1(January 6, 2012)
- ISSN：1523-7052
文摘
Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The absolute configuration of 1 was determined by spectral methods and single crystal X-ray diffraction analysis. Compound 4 and the synthesized compound 5 exhibited significant cytotoxicity.