Palladium-Catalyzed Synthesis of α-Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction
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- 作者：Zhen-Bang Chen ; Ying Zhang ; Qing Yuan ; Fang-Ling Zhang ; Yong-Ming Zhu ; Jing-Kang Shen
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：February 19, 2016
- 年：2016
- 卷：81
- 期：4
- 页码：1610-1616
- 全文大小：458K
- ISSN：1520-6904
文摘
An efficient one-pot synthesis of α-iminonitriles from readily available aryl halides via palladium-catalyzed double isocyanide insertion and elimination has been developed, without using various hypertoxic cyanides and excess oxidants. Furthermore, the utility of this reaction was demonstrated by the rapid total synthesis of quinoxaline and the reaction of functional groups exchanged with aryl halides.