Silver-Mediated Oxidative Trifluoromethylation of Alcohols to Alkyl Trifluoromethyl Ethers
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- 作者：Jian-Bo Liu ; Xiu-Hua Xu ; Feng-Ling Qing
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：October 16, 2015
- 年：2015
- 卷：17
- 期：20
- 页码：5048-5051
- 全文大小：404K
- ISSN：1523-7052
文摘
The development of an efficient and practical method for the preparation of alkyl trifluoromethyl ethers is urgently demanding. The silver-mediated oxidative O-trifluoromethylation of primary, secondary, and tertiary alcohols with TMSCF3 under mild reaction conditions is established to provide a novel approach to a broad range of alkyl trifluoromethyl ethers. Further, this method is applied to the late-stage O-trifluoromethylation of complex natural products and prescribed pharmaceutical agents.