Campechic Acids A and B: Anti-invasive Polyether Polyketides from a Soil-Derived Streptomyces

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• 作者：Linkai Yu ; Martha E. Trujillo ; Satoshi Miyanaga ; Ikuo Saiki ; Yasuhiro Igarashi
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：976-982
• 全文大小：310K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

Campechic acids A (1) and B (2), two new polyketides, were isolated from the culture extract of Streptomyces sp., and their structures were determined by NMR and MS spectroscopic analysis. Campechic acids are polyether-polyketides functionalized by two tetrahydrofuran rings, an enolized 1,3-diketone, and multiple methyl substitutions. Absolute configuration of nine stereogenic centers in 1, except for four chiral centers in the cyclic ether moieties, was determined by the ¹H NMR anisotropy method in combination with chemical degradation. Campechic acids exhibited potent inhibitory effects on tumor cell invasion with IC₅₀ values in the nanomolar to submicromolar range.