Design, Synthesis, and Multivariate Quantitative Structure-Activity Relationship of Salicylanilides-Potent Inhibitors of Type III Secretion in Yersinia

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• 作者：Markus K. Dahlgren ; Anna M. Kauppi ; Ing-Marie Olsson ; Anna Linusson ; Mikael Elofsson
• 刊名：Journal of Medicinal Chemistry
• 出版年：2007
• 出版时间：November 29, 2007
• 年：2007
• 卷：50
• 期：24
• 页码：6177 - 6188
• 全文大小：367K
• 年卷期：v.50,no.24(November 29, 2007)
• ISSN：1520-4804

文摘

Analogues to the salicylanilide N-(4-Chlorophenyl)-2-acetoxy-3,5-diiodobenzamide, 1a, an inhibitor of typeIII secretion (T3S) in Yersinia, were selected, synthesized, and biologically evaluated in three cycles. First,a set of analogues with variations in the salicylic acid ring moiety was synthesized to probe possible structuralvariation. A basic structure-activity relationship was established and then used to cherry-pick compoundsfrom a principal component analysis score plot of salicylanilides to generate a second set. A third set withincreased likelihood of biological activity was designed using D-optimal onion design. A quantitativestructure-activity relationship model using hierarchical partial least-square regression to latent structures(Hi-PLS) was computed using PLS score vectors of building blocks correlated to the % inhibition of T3Sas a response. A PLS discriminant analysis (PLS-DA) model was derived using the same descriptor set asthat for the Hi-PLS model. Both models were validated with an external test set.