In Situ Phototriggered Disulfide-Cross-Link Nanoparticles for Drug Delivery

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• 作者：Yunlong Yang ; Yan Li ; Qiuning Lin ; Chunyan Bao ; Linyong Zhu
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：March 15, 2016
• 年：2016
• 卷：5
• 期：3
• 页码：301-305
• 全文大小：346K
• ISSN：2161-1653

文摘

In situ forming redox responsive nanoparticles have been developed based on amphiphilic copolymers-phototriggered disulfide-cross-link macromolecules (PDCM). Upon 405 nm light irradiation, the macrocyclic thiol caged coumarin phototrigger in PDCM can release free thiols, and these free thiols subsequently realize in situ disulfide cross-link via reacting with a pyridyl disulfide group inside the PDCM assembled nanoparticles. The phototriggered disulfide-cross-link strategy can be conducted rapidly, conveniently, and cleanly without adding any cross-linkers or catalysts. Via changing irradiation condition, nanoparticles with different cross-link densities can be formed. These nanoparticles can encapsulate hydrophobic guest molecules with good stability and achieve redox-triggered release under GSH reduction. Intracellular experiments show that these nanoparticles can be used as promising drug carriers.