Efficient Synthesis of Protein Mimics by Sequential Native Chemical Ligation

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• 作者：Helmus van de Langemheen ; H. (Linda) C. Quarles van Ufford ; John A. W. Kruijtzer ; Rob M. J. Liskamp
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 18, 2014
• 年：2014
• 卷：16
• 期：8
• 页码：2138-2141
• 全文大小：340K
• 年卷期：v.16,no.8(April 18, 2014)
• ISSN：1523-7052

文摘

Synthetic mimics of protein surfaces have the potential to become inhibitors of protein鈥損rotein interactions or even synthetic vaccines. However, the synthesis of these complicated molecular constructs is still difficult. Here we describe an efficient and versatile synthesis of protein mimics containing up to three different cyclic peptides. Using a sequential native chemical ligation strategy, peptide loops containing a thioester handle were introduced onto a triazacyclophane scaffold bearing orthogonal protected cysteine residues.