Synthesis of Cyclic Peptides Containing a Thioester Handle for Native Chemical Ligation

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• 作者：Helmus van de Langemheen ; Arwin J. Brouwer ; Johan Kemmink ; John A. W. Kruijtzer ; Rob M. J. Liskamp
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：November 16, 2012
• 年：2012
• 卷：77
• 期：22
• 页码：10058-10064
• 全文大小：351K
• 年卷期：v.77,no.22(November 16, 2012)
• ISSN：1520-6904

文摘

The synthesis of cyclic peptides containing a thioester handle using a sulfo-click linker is reported. These cyclic peptides can be coupled to N-terminal cysteine-containing constructs via native chemical ligation. A successful application of a cyclic peptide bearing a thioester handle in native chemical ligation is shown by a high yielding ligation.