Concise Total Syntheses of (+)-Strictifolione and (6R)-6-[(4R,6R)-4,6-Dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one

详细信息    查看全文

• 作者：Shibing Tang ; Xingang Xie ; Xiaolei Wang ; Liuer He ; Ke Xu ; Xuegong She
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：December 3, 2010
• 年：2010
• 卷：75
• 期：23
• 页码：8234-8240
• 全文大小：887K
• 年卷期：v.75,no.23(December 3, 2010)
• ISSN：1520-6904

文摘

Concise and efficient asymmetric total syntheses of (+)-strictifolione 1 and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one 2 have been achieved based on the strategic application of one-pot double allylboration and ring-closing metathesis reactions. The total syntheses proceeded in only five and seven steps, respectively, from readily available 3-butenal and represent the shortest syntheses of 1 and 2 reported to date.