Efficient and Regioselective Synthesis of 5-Hydroxy-2-isoxazolines: Versatile Synthons for Isoxazoles, β-Lactams, and γ-Amino Alcohols

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• 作者：Shibing Tang ; Jinmei He ; Yongquan Sun ; Liuer He ; Xuegong She
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：March 19, 2010
• 年：2010
• 卷：75
• 期：6
• 页码：1961-1966
• 全文大小：819K
• 年卷期：v.75,no.6(March 19, 2010)
• ISSN：1520-6904

文摘

An efficient and highly regioselective protocol was developed for the preparation of 5-hydroxy-2-isoxazolines, which have been proved to be versatile synthons for isoxazles, β-hydroxy oximes, and γ-amino alcohols. β-Lactams, commonly embedded in the skeletons of bioactive natural products, were also synthesized in two steps from β-hydroxy oximes, providing a new strategy for the synthesis of this kind of compounds.