Effective Surface Charge Density Determines the Electrostatic Attraction between Nanoparticles and Cells

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• 作者：Gaoxing Su ; Hongyu Zhou ; Qingxin Mu ; Yi Zhang ; Liwen Li ; Peifu Jiao ; Guibin Jiang ; Bing Yan
• 刊名：The Journal of Physical Chemistry C
• 出版年：2012
• 出版时间：March 1, 2012
• 年：2012
• 卷：116
• 期：8
• 页码：4993-4998
• 全文大小：382K
• 年卷期：v.116,no.8(March 1, 2012)
• ISSN：1932-7455

文摘

We examine the origin of the electrostatic attraction between nanoparticle (NP) and cells by synthesizing a NP array with a continuous change in surface charge density (SCD). This attraction does not show a linear and continuous change, but a sharp increase as the positive SCD increases. The results of zeta potential measurements of the naked and protein bound NPs reveal that excessive charges on surface ligands are partially shielded, and the noncovalent protein bindings do not influence NP鈥揷ell electrostatic interactions. The effective SCD on the outmost layer of NPs determined the electrostatic attraction between NPs and cells