Sensitization of Non-small Cell Lung Cancer Cells to Cisplatin by Naturally Occurring Isothiocyanates

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• 作者：Anthony J. Di Pasqua ; Charles Hong ; Mona Y Wu ; Erin McCracken ; Xiantao Wang ; Lixin Mi ; Fung-Lung Chung
• 刊名：Chemical Research in Toxicology
• 出版年：2010
• 出版时间：August 16, 2010
• 年：2010
• 卷：23
• 期：8
• 页码：1307-1309
• 全文大小：190K
• 年卷期：v.23,no.8(August 16, 2010)
• ISSN：1520-5010

文摘

We show that naturally occurring isothiocyanates (ITCs) sensitize human non-small cell lung cancer cells to cisplatin. Moreover, the structure of the ITC side chain moiety is important for sensitization. In NCI-H596 cells, 20 μM benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) enhance the efficacy of various concentrations of cisplatin, but sulforaphane (SFN) does not. Reducing the concentration of BITC and PEITC to 10 μM still allows for the sensitization of cells to cisplatin. Neither cellular platinum accumulation nor DNA platination account for this increased cytotoxicity. BITC and PEITC deplete β-tubulin, but SFN does not; this correlates with and may be important for sensitization.