Structural Revision of Cephalosporolide J and Bassianolone

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• 作者：Liyan Song ; Ka-Ho Lee ; Zhenyang Lin ; Rongbiao Tong
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：February 7, 2014
• 年：2014
• 卷：79
• 期：3
• 页码：1493-1497
• 全文大小：292K
• ISSN：1520-6904

文摘

The NMR spectra for three 鈥渘atural鈥?products: cephalosporolide C (Ces-C), cephalosporolide J (Ces-J), and bassianolone were found to be identical, and we proposed that Ces-C was the correct structure for the reported spectra. The first total synthesis of the proposed structure for Ces-J was achieved to support our structural revision for Ces-J. Chemical transformations of bassianolone and computational prediction of ¹³C NMR spectra allowed us to conclude that Ces-C was the correct structure for bassianolone. Our synthetic and computational studies suggested that these 鈥渄ifferent鈥?natural products Ces-C, Ces-J, and bassianolone have the same structure: Ces-C.