Oxidative Cross-Coupling through Double Transmetallation: Surprisingly High Selectivity for Palladium-Catalyzed Cross-Coupling of Alkylzinc and Alkynylstannanes
详细信息 查看全文
- 作者：Yingsheng Zhao ; Haibo Wang ; Xiaohui Hou ; Yanhe Hu ; Aiwen Lei ; Heng Zhang ; Lizheng Zhu
- 刊名：Journal of the American Chemical Society
- 出版年：2006
- 出版时间：November 29, 2006
- 年：2006
- 卷：128
- 期：47
- 页码：15048 - 15049
- 全文大小：55K
- 年卷期：v.128,no.47(November 29, 2006)
- ISSN：1520-5126
文摘
Two different organometallic reagents now can cross-couple together with the oxidative cross-coupling strategy. Palladium catalyzed oxidative cross-couplings of alkylzinc and alkynylstannane reagents using desyl chloride as the oxidant have been explored, which produce the desired Csp-Csp3 cross-coupling product in surprisingly high selectivity and yields. The current catalytic system tolerates the presence of 
-H, and the reactions using long chain alkyl zinc reagents gave the cross-coupling product in excellent yields and selectivities.
-H, and the reactions using long chain alkyl zinc reagents gave the cross-coupling product in excellent yields and selectivities.