Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation

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• 作者：Yitzhak Mastai ; Antje Vö ; lkel ; Helmut Cö ; lfen
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：February 27, 2008
• 年：2008
• 卷：130
• 期：8
• 页码：2426 - 2427
• 全文大小：99K
• 年卷期：v.130,no.8(February 27, 2008)
• ISSN：1520-5126

文摘

In this study, it is shown that preparative density gradient ultracentrifugation can be applied to separate racemate crystals from excess enantiomer crystals. This was demonstrated for alanine crystals separated in a 50 wt % Nycodenz gradient. The recovery rates of the pure enantiomers from the mixtures were good (70-90%), and the separation method showed accuracy in the third digit of the density. As such density differences between racemate and enantiomers can be found for a wide range of crystalline chiral compounds, the presented separation method should be applicable to a large variety of substances on a preparative scale.