Novel Monoisotopic 109AgNPET for Laser Desorption/Ionization Mass Spectrometry

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• 作者：Joanna Nizio艂 ; Wojciech Rode ; Barbara Laskowska ; Tomasz Ruman
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：February 5, 2013
• 年：2013
• 卷：85
• 期：3
• 页码：1926-1931
• 全文大小：286K
• 年卷期：v.85,no.3(February 5, 2013)
• ISSN：1520-6882

文摘

Preparation is described of the surface of the first monoisotopic cationic ¹⁰⁹Ag nanoparticles (AgNPs), covering commercial and modified MALDI targets, along with examples of the use in MS analyses of various low-molecular-weight (LMW) organic compounds, including alkaloids, saccharides, amino acids, nucleosides, nucleic bases, and other organics. The new targets, compared to those covered by naturally occurring silver, allow analyte detection with higher sensitivity, mass accuracy, and resolution. Moreover, monoisotopic triatomic silver cations ¹⁰⁹Ag₃⁺ appear to be applicable for analyte cationization.