Absolute Configuration of (鈭?-Centratherin, a Sesquiterpenoid Lactone, Defined by Means of Chiroptical Spectroscopy
详细信息 查看全文
- 作者：Fernando M. S. Junior ; Cody L. Covington ; Ana Carolina F. de Albuquerque ; Jonathas F. R. Lobo ; Ricardo M. Borges ; Mauro B. de Amorim ; Prasad L. Polavarapu
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：November 25, 2015
- 年：2015
- 卷：78
- 期：11
- 页码：2617-2623
- 全文大小：440K
- ISSN：1520-6025
文摘
(鈭?-Centratherin is a bioactive sesquiterpenoid lactone, whose absolute configuration (AC) was not established, but has been proposed based on those of germacrane precursors. To verify this proposal, the experimental electronic circular dichroism (ECD), electronic dissymmetry factor (EDF), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational dissymmetry factor (VDF) spectra of (鈭?-centratherin have been analyzed with the corresponding density functional theoretical predictions. These analyses suggest the AC of naturally occurring (鈭?-centratherin to be (6R,7R,8S,10R,2鈥?i>Z).