Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata

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• 作者：Sarath P. Gunasekera ; Lorelie Imperial ; Christiana Garst ; Ranjala Ratnayake ; Long H. Dang ; Valerie J. Paul ; Hendrik Luesch
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：July 22, 2016
• 年：2016
• 卷：79
• 期：7
• 页码：1867-1871
• 全文大小：281K
• 年卷期：0
• ISSN：1520-6025

文摘

The isolation, structure determination, and biological activities of a new linear pentapeptide, caldoramide (5), from the marine cyanobacterium Caldora penicillata from Florida are described. Caldoramide (5) has structural similarities to belamide A (4), dolastatin 10 (1), and dolastatin 15 (2). We profiled caldoramide against parental HCT116 colorectal cancer cells and isogenic cells lacking oncogenic KRAS or hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α). Caldoramide (5) showed differential cytotoxicity for cells containing both oncogenic KRAS and HIF over the corresponding knockout cells. LCMS dereplication indicated the presence of caldoramide (5) in a subset of C. penicillata samples.