Rapidly Self-Expandable Polymeric Stents with a Shape-Memory Property

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• 作者：Mei-Chin Chen ; Hung-Wen Tsai ; Yen Chang ; Wei-Yun Lai ; Fwu-Long Mi ; Chin-Tang Liu ; Hen-Sheng Wong ; Hsing-Wen Sung
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：8
• 期：9
• 页码：2774 - 2780
• 全文大小：1266K
• 年卷期：v.8,no.9(September 2007)
• ISSN：1526-4602

文摘

A novel biodegradable stent, made of chitosan films cross-linked with an epoxy compound, with a shape-memoryproperty was developed. To reduce their crystallinity, glycerol and poly(ethylene oxide) were blended in thechitosan films. The mechanical properties of the prepared stent were studied using a commercially availablemetallic stent as a control. After blending, the ductility of the chitosan films was improved, and the compressivestrength of the stent was significantly enhanced. The metallic stent could tolerate elastic deformations of 10%before becoming irreversibly deformed, while the polymeric stent was able to withstand deformations up to 30%and still regain its original configuration. The developed stent could rapidly expand (~150 s) from its crimped(temporary) to fully expanded (permanent) states stimulated by hydration, which is advantageous consideringavoiding its migration during in vivo deployment. In the preliminary animal study, the implanted stent was foundto be intact, and no thrombus formation was seen in the stent-implanted vessel. This degradable stent can be anattractive alternative to metallic stents and may serve as a useful vehicle for local drug delivery.