Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center

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• 作者：Kang Liu ; Huai-Long Teng ; Lu Yao ; Hai-Yan Tao ; Chun-Jiang Wang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：May 3, 2013
• 年：2013
• 卷：15
• 期：9
• 页码：2250-2253
• 全文大小：307K
• 年卷期：v.15,no.9(May 3, 2013)
• ISSN：1523-7052

文摘

An unprecedented Ag(I)-catalyzed asymmetric desymmetrization of spiro cyclohexadienone lactones has been developed successfully, which performs well over a broad scope of substrates and provides a facile access to optically active spirolactone-pyrrolidines in high yields with excellent levels of diastereo-/enantioselectivities.