Nitrosporeusines A and B, Unprecedented Thioester-Bearing Alkaloids from the Arctic Streptomyces nitrosporeus

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• 作者：Aigang Yang ; Longlong Si ; Zhenping Shi ; Li Tian ; Dong Liu ; Demin Zhou ; Peter Proksch ; Wenhan Lin
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：15
• 期：20
• 页码：5366-5369
• 全文大小：243K
• 年卷期：v.15,no.20(October 18, 2013)
• ISSN：1523-7052

文摘

Chemical examination of an arctic actinomycete Streptomyces nitrosporeus resulted in the isolation of two new alkaloids named nitrosporeusines A (1) and B (2), an unprecedented skeleton containing benzenecarbothioc cyclopenta[c]pyrrole-1,3-dione. Their structures were determined through extensive spectroscopic analyses in association with X-ray single crystal diffraction. Both 1 and 2 exhibited inhibitory activities against the H1N1 virus in MDCK cells.