Optimization of a Hydrogenation Process using Real-Time Mid-IR, Heat Flow and Gas Uptake Measurements

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• 作者：Benjamin J. Littler ; Adam R. Looker ; Todd A. Blythe
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：November 19, 2010
• 年：2010
• 卷：14
• 期：6
• 页码：1512-1517
• 全文大小：339K
• 年卷期：v.14,no.6(November 19, 2010)
• ISSN：1520-586X

文摘

This paper describes using real-time mid-IR, heat flow, and gas uptake data to optimize the hydrogenation of a nitroaromatic to an aniline that had been difficult to control during a previous campaign in the pilot plant. A bimetallic Pt/V catalyst was identified that eliminated the buildup of reaction intermediates and consequently resulted in an inherently more controllable process. The real-time analytics were then used to rapidly optimize the reaction conditions and develop strategies for controlling the reaction rate in the plant should an unexpected deviation occur.