An Investigation into the Tether Length and Substitution Pattern of Arene-Substituted Complexes for Asymmetric Transfer Hydrogenation of Ketones

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• 作者：Fung K. Cheung ; Changxue Lin ; Franco Minissi ; Adriana Lorente Crivill&eacute ; Mark A. Graham ; David J. Fox ; Martin Wills
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：October 25, 2007
• 年：2007
• 卷：9
• 期：22
• 页码：4659 - 4662
• 全文大小：83K
• 年卷期：v.9,no.22(October 25, 2007)
• ISSN：1523-7052

文摘

ABLE>jn00001>A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of regeneration of hydride "Ru-H" and increasedrate of ketone reduction. Several classes of ketone were reduced in enantiomeric excesses of up to 97%. Substituents on the arene ring ofthe catalyst influence the reaction rate and enantioselectivity.