Radioprotective-Antimutagenic Effects of Rosemary Phenolics against Chromosomal Damage Induced in Human Lymphocytes by -rays
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- 作者：M. J. Del Bañ ; o ; J. Castillo ; O. Benavente-Garcí ; a ; J. Lorente ; R. Martí ; n-Gil ; C. Acevedo ; and M. Alcaraz
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2006
- 出版时间：March 22, 2006
- 年：2006
- 卷：54
- 期：6
- 页码：2064 - 2068
- 全文大小：308K
- 年卷期：v.54,no.6(March 22, 2006)
- ISSN：1520-5118
文摘
The radioprotective effects of carnosic acid (CA), carnosol (COL), and rosmarinic acid (RO) againstchromosomal damage induced by 
ages/gifchars/gamma.gif" BORDER=0 >-rays, compared with those of L-ascorbic acid (AA) and theS-containing compound dimethyl sulfoxide (DMSO), were determined by use of the micronucleustest for antimutagenic activity, evaluating the reduction in the frequency of micronuclei (MN) incytokinesis-blocked cells of human lymphocytes before and after ages/gifchars/gamma.gif" BORDER=0 >-ray irradiation. With treatmentbefore ages/gifchars/gamma.gif" BORDER=0 >-irradiation, the most effective compounds were, in order, CA > RO ages/entities/ge.gif"> COL > AA > DMSO.The radioprotective effects (antimutagenic) with treatment after ages/gifchars/gamma.gif" BORDER=0 >-irradiation were lower, and the mosteffective compounds were CA and COL. RO and AA presented small radioprotective activity, andthe sulfur-containing compound DMSO lacked ages/gifchars/gamma.gif" BORDER=0 >-ray radioprotection capacity. Therefore, CA and COLare the only compounds that showed a significant antimutagenic activity both before and afterages/gifchars/gamma.gif" BORDER=0 >-irradiation treatments. These results are closely related to those reported by other authors on theantioxidant activity of the same compounds, and the degree of effectiveness depends on their structure.Furthermore, the results for treatments before and after ages/gifchars/gamma.gif" BORDER=0 >-ray irradiation suggest the existence ofdifferent radioprotective mechanisms in each case.Keywords: Rosemary; polyphenols; antioxidant; radical scavenger; micronuclei; antimutagenic;radioprotection; radiation effects; carnosic acid; carnosol; rosmarinic acid