Cytotoxic Clerodane Diterpenes from Casearia rupestris
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- 作者：Gerardo M. Vieira-Ju虂nior ; Luiz A. Dutra ; Paulo M. P. Ferreira ; Manoel O. de Moraes ; Leti虂cia V. Costa Lotufo ; Cla虂udia do O虂 Pessoa ; Roseli Buzanelli Torres ; Nivaldo Boralle ; Vanderlan da S. Bolzani ; Alberto J. Cavalheiro
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：April 25, 2011
- 年：2011
- 卷：74
- 期：4
- 页码：776-781
- 全文大小：795K
- 年卷期：v.74,no.4(April 25, 2011)
- ISSN：1520-6025
文摘
Four new clerodane diterpenes, casearupestrins A鈭扗 (1鈭?b>4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.