Using Medicinal Chemistry To Solve an Old Medical Mystery

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• 作者：William B. Hinshaw ; Louis D. Quin
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：January 10, 2013
• 年：2013
• 卷：4
• 期：1
• 页码：2-4
• 全文大小：142K
• 年卷期：v.4,no.1(January 10, 2013)
• ISSN：1948-5875

文摘

The logic behind the traditional medicinal chemistry technique of designing a synthetic enzyme substrate to mimic a natural one is used to uncover the identity of the unknown cause of two legacy industrial diseases by comparing the reported symptoms to two side effects of a modern synthetic.