Palladium(II)-Catalyzed Intramolecular Oxidative C–H/C–H Cross-Coupling Reaction of C3,N-Linked Biheterocycles: Rapid Access to Polycyclic Nitrogen Heterocycles
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- 作者：Serena Mantenuto ; Cecilia Ciccolini ; Simone Lucarini ; Giovanni PiersantiGianfranco Favi ; Fabio Mantellini
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 3, 2017
- 年：2017
- 卷：19
- 期：3
- 页码：608-611
- 全文大小：397K
- ISSN：1523-7052
文摘
A Pd(II)-catalyzed intramolecular oxidative C–H/C–H cross-coupling has been developed for the direct construction of valuable polycyclic heteroarene scaffolds. From a retrosynthetic point of view, the strategic formation of a C–C bond via C(sp2)–H/C(sp2)–H dehydrogenative coupling across C3,N-linked biheterocyclic precursors may be useful in de novo syntheses of indole-derived natural products and pharmaceuticals. The reaction exhibited good functional group/heterocycle tolerance, and a proposed mechanism involving an azoylpalladium complex is also supported.